RESEARCH & DEVELOPMENT

RESEARCH & DEVELOPMENT

Botanix has 100s of scientific brains with restless hands,  We study with different herbs and have applied for deep research and publications .. As a result we are entering into Global market with newly  discovered molecules .

The Botanix  process has been designed in such a way that gives advantage of maximum resistant against humidity and temperature to our end
preparations .This provides the best possible protection & longer shelf life for end formulations. Technically we have spent maximum time to improve maximum aromatic value, more active ingredients & flavours & taste for better application in medicines, nutraceuticals& cosmetics.

  • Our R&D constantly works on ADME : Absorption, Distribution, Metabolism & Excretion.
  • Numerous researches have been done in R&D lab to make particles more soluble, more denser, less bitter & less in moisture.
  • We are focusing on green technology too We have set up a separate R&D Centre in 1500 sq. ft. area.

Our R&D has achieved some KEY BENEFITS through our ingredients which has successfully kept our company ahead than any other producers.

1.Extraction Techniques

Choosing the appropriate extraction method is crucial for isolating bioactive compounds efficiently while maintaining their integrity.

  •  Solvent Extraction: Using ethanol, methanol, or water as solvents.
  •  Supercritical Fluid Extraction (SFE): Ideal for thermolabile compounds.
  •  Ultrasound-Assisted Extraction (UAE): For increased yield and efficiency.
  •  Microwave-Assisted Extraction (MAE): For rapid extraction.
  •  Hydrodistillation or Steam Distillation: Specific for essential oils (e.g., orange).

2. Analytical Characterization

Comprehensive analysis ensures quality, safety, and efficacy:

Phytochemical Profiling: Identifying primary active constituents.

  • Curcumin in turmeric (Curcuma longa).
  • Withanolides in Ashwagandha.
  • Bacosides in Bacopa monnieri.
  • Andrographolides in Andrographis paniculata.
  • Capsaicinoids in Red Chili.
  • Hydroxycitric acid in Garcinia.
  • Flavanones and ascorbic acid in Orange.
  • Chlorogenic acid and caffeine in Coffee Beans.

    Techniques

    •  High-Performance Liquid Chromatography (HPLC) & Ultra-HighPerformance Liquid Chromatography (UHPLC) for quantitative and qualitative analysis.
    •  Gas Chromatography-Mass Spectrometry (GC-MS) for volatile compounds.
    •  Fourier-Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) for molecular characterization.
    •  Liquid Chromatography-Mass Spectrometry (LC-MS) for high-precision analysis

    3. Standardization

    • Developing standardized extracts with consistent levels of active components.
    • Use of biomarkers like curcumin, withanolides, or bacosides to ensure reproducibility.
    • Validating with advanced analytical techniques such as HPLC and mass spectrometry

    4. Biological Evaluation

    •  In vitro Studies: Antioxidant, anti-inflammatory, antimicrobial screenings.
    •  In vivo Studies: Pharmacokinetics and pharmacodynamics in model organisms.
    •  Clinical Studies: Safety and efficacy trials in humans for therapeutic claims.

    5. Formulation Development

    • Developing stable, bioavailable forms like capsules, powders, or liquid extracts.

    • Enhancing delivery with systems like nanoparticles and liposomes.

    6. Toxicological and Safety Studies

    •  Acute and chronic toxicity studies to ensure safety at therapeutic doses.
    •  Testing for heavy metals, pesticides, and microbial contamination.

    7. Future Directions in Analytical R&D

    •  Green Extraction Technologies Utilizing eco-friendly methods like microwave-assisted extraction and enzyme-assisted extraction to reduce environmental impact.
    •  Omics Approaches Incorporating genomics, proteomics, and metabolomics for a deeper understanding of how these extracts interact with the human body.
    •  Al and Machine Learning in Formulation Leveraging data-driven techniques to predict optimal combinations and dosages for synergistic effects.
    •  Regulatory Compliance Aligning with global standards like GRAS (Generally Recognized as Safe) and pharmacopoeial standards for international markets